Aim and Scope:

N-of-1: Clinical Case Studies (hereafter referred to as N-of-1), aims to be a cutting-edge peer-reviewed resource of high quality case reports, case studies, case series, and n-of-1 clinical trials, with the intention of providing baseline evidence for future clinical research. 

N-of-1 is an official journal of Whole Systems Research Institute (hereafter referred to as WSRI), a research collaborative aimed at supporting the holistic, systems-based research initiatives of Whole Systems Healthcare (hereafter referred to as WSHC). N-of-1 will be comprehensive and integrative by reporting potential novel treatments and outcomes for conditions from across the spectrum of healthcare. 

To be consistent in these aims, manuscripts submitted to N-of-1 should demonstrate at least one of the following: 

  • Novel or additional perspective on the understanding of health conditions in the clinical setting.
  • Novel or additional perspective on understanding social impacts of health on the individual, and on managing those situations.
  • Demonstrate efficacy or inefficacy of treatments or modalities in clinical situations
  • Document efficacy or inefficacy of less understood treatments or modalities
  • Document the efficacy or inefficacy of less understood medical professions
  • Describe an integrative approach to patient care

Fees and Funding:

In order to provide peer-review services, editing and formatting of journal articles, as well as database administration services, N-of-1 requires a submission fee of $27.50 to be paid at time of initial article submission. Should articles be approved for editing, there will be an additional $105.00 editing fee. Fees are subject to change. Please contact info@nof1journal.org for updated submission and editing fees. 

Copyright Agreement:

N-of-1 retains the rights to all published material. Authors may distribute preprints and postprints, provided these distributions contain copyright acknowledgement for N-of-1 and the appropriate Digital Object Identifier (DOI). 

Authors whose manuscripts are published by N-of-1 agree to allow N-of-1 to use published data for future research, including inclusion in case series pertaining to the subject or treatment modality.

Ethics:

Submissions must comply with NIH Guiding Principles for Ethical Research, which can be accessed at https://www.nih.gov/health-information/nih-clinical-research-trials-you/guiding-principles-ethical-research. 

Authors may appeal a manuscript rejection decision by drafting a letter to submissions@nof1journal.org with a point by point response to any concerns raised by reviews and/or journal editors.